J.P. Morgan analyst Doug Anmuth commented on the sudden departure saying: "We believe their departure comes as a surprise given Instagram's success and its growing importance within Facebook". It is less crowded than the main Facebook app, and perceived to be a kinder social network.
What have the pair said?
Spokespeople for Facebook and Instagram declined to comment further on why the executives had made a decision to step down, referring back to Systrom's blog post.
He added: "Building new things requires that we step..."
There was no animosity in the blog post. "We look forward to watching what these innovative and extraordinary companies do next", Systrom wrote.
So what's behind the departures?
In an interview with The Wall Street Journal that was conducted before Monday's announcement, Kevin makes clear he has no regrets about having sold Instagram to Facebook back in 2012. Senior Facebook officials had known the two men were frustrated working within a large company and had begun making preparations for them to leave, another person familiar with the matter said.
Second woman accuses Kavanaugh of sexual misconduct
But he added "unless there's something more" to back up her accusation, he's "not going to ruin Judge Kavanaugh's life over this". Mark Judge, the friend who was allegedly in the room with Kavanaugh and Ford, denied having any recollection of the party.
Facebook has been pivoting Instagram to incorporate other revenue streams besides just advertisements, rolling out shopping in its Stories feature, alongside a new dedicated shopping channel in the "Explore" area.
Facebook shares fall after Instagram co-founders step down from the company.
Instagram became popular in Silicon Valley nearly immediately.
Mr Systrom and Mr Krieger started the image sharing site in 2010, and continued to run the service after it was acquired by Facebook. "Now, we'll be able to work even more closely with the Instagram team to also offer the best experiences for sharing attractive mobile photos with people based on your interests". Algorithmic ordering of the timeline. and ads, so many ads.
He later tweeted, "The @instagram journey is one I won't forget".
Instagram attracts a younger cohort of users who are critical to Facebook's growth.
Indeed not. In fact it echoes what happened with WhatsApp.
The departures of Systrom and Krieger create uncertainty around the app.
Tras la salida de Caputo el dólar tuvo una fuerte suba
Respecto de la política cambiaria, Sandleris fue uno de los defensores de la flotación del tipo de cambio, como "amortiguador" de los shocks externos.
Mr Systrom and Mr Krieger met while studying at Stanford University.
At the time Instagram was free of advertising, with a loyal following of 31 million users. Facebook's stock has taken a dramatic plunge in the wake of the scandal with Cambridge Analytica, which used an online quiz to harvest and collate Facebook users' information online.
It was also ad-free.
What has the social media chatter been?
BELEAGUERED social network Facebook has taken another hit after both founders of its photo-sharing app Instagram announced their resignations and plans to leave the company within weeks.
"Was it a slight dig from Systrom with the "again"?"
¿Qué falta para que Marcos Díaz deje Huracán y pase a Boca?
A pesar de que su nombre resuena como uno de los posibles reemplazantes, nadie de parte del Xeneize ni de la T se comunicó con él. El jugador de Huracán tendría acordado su contrato con el Xeneize .