Djokovic defeated third-ranked Argentinian Juan Martin del Potro with a three sets win, 6-3, 7-6 (7-4), 6-3.
6-3 victory under the roof at Arthur Ashe stadium - it was raining in NY - pulled him level with Pete Sampras for third on the all-time men's list.
Djokovic's remarkable 2018 also saw him create history last month as he became the first singles player to win the Golden Masters after finally winning the Cincinnati Masters.
Del Potro backed Djokovic to surpass Federer's mark of 20 Slams.
While many hope del Potro gets that second major someday, including Djokovic - he is severely owed by the tennis gods - his foe was simply too good in the opening set.
"1-2-3;-Osaka-at-No. -7-after-US-Open-title">rightfully back atop the rankings for the first time in 3½ years, with Nadal at No. 1, Federer at No. 2 and, as of Monday, Djokovic at No. 3. Ahead 40-0 he wasn't able to capitalize on any of the three game points, then went onto make two forehand errors to surrender his serve.
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Between them, Federer, Nadal and Djokovic have won 47 of the last 55 slam titles, but Del Potro has no regrets, saying: "It is a big challenge to take these kind of tournaments from them".
Back from career-threatening wrist problems, Del Potro has shone throughout this tournament, but will have his work cut out to deny former world number one Djokovic if the Serbian reproduces the form he showed on Friday.
Djokovic, who won Wimbledon in July, has now won 14th grand slam titles - putting him level with Pete Sampras and behind only Roger Federer (20) and Rafael Nadal (17) on the all-time men's singles list. "I really am. I feel like these guys, rivalries with these guys, matches with Federer and Nadal, have made me the player I am, have shaped me into the player I am today", Djokovic said, his shiny silver U.S. Open trophy resting a few feet away.
He added: "I would like to congratulate Juan Martin".
It's del Potro's first major final since he won his only one in the 2009 U.S. Open by beating Roger Federer. "Ever since, the tennis is completely different for me".
While controversy marred her win over Williams, leaving the champion in tears during the presentation ceremony, it should be noted that Osaka was a set up and performing magnificently when the chaos started.
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En una respuesta llorosa a su victoria, Osaka dijo que deseaba que las circunstancias de su victoria hubieran sido diferentes. La tenista perdió la compostura y arremetió contra él: " Me debes una disculpa, eres un mentiroso y un ladrón ".
"I was very disappointed with my performance that day".
"I feel better with my backhand, but it's not good enough to win a title like this or to win the top guys in a row", del Potro said past year after falling to Nadal in the US Open semifinals.
The 2.4 overnight rating is up 32% from previous year (1.9 for Sloane Stephens and Madison Keys of the U.S.) and 79% higher than 2016 (1.4 for Angelique Kerber vs. Karolina Pliskova).
The sixth seed had suffered in the ferocious heat and humidity through the early days of the season's final Grand Slam but dropped only two sets for the tournament and none since the second round.
He was also taking longer and longer to serve, but dug deep to hold for 4-4 in a hugely dramatic game lasting just over 20 minutes.
There may have been no game more important to Djokovic's win or simply entertaining than the eighth game of the second set.
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Porque si bien Brown debió liquidar la historia por penales, tuvo varias chances para quedarse con el triunfo en tiempo regular. Pero Campaña otra vez se hizo gigante a los 44′, para volar sobre su derecha y taparle el penal a Juan Olivares.